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IMM-H007
CAS No. : 1221412-23-2
Biological Activity：IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[2][3].
Research Area：Metabolic Disease|Inflammation/Immunology|Cardiovascular Disease
Targets：AP-1|NF-κB|TGF-β Receptor|JNK|AMPK
Related Small Molecules:Akt/NF-κB/JNK-IN-1;AMPK activator 4;JNK3 inhibitor-2;Icariside F2;IKKγ NBD Inhibitory Peptide TFA;Mangiferin;Antioxidant agent-5;ML347;ALPK1-IN-1;Regaloside A;IMD-ferulic;SN52;5-Aminosalicylic Acid-D3 hydrochloride;Ginsenoside Rg1;Echinulin;Licochalcone D;QNZ;LDN193189 (GMP);TGFβRI-IN-4;ZLN024;YLF-466D;BIZ 114;ALK5-IN-6;NF-κΒ activator 1;Berbamine;TGFβ-IN-1;JIP-1(153-163) TFA
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