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hA2A/hCA XII modulator 1

CAS No. : 2548963-55-7

Biological Activity：hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA_2A adenosine receptor (hA_2AAR) antagonist with K_is of 6.4 nM, 4.819 μM, >30 μM for hA_2AAR, hA₁AR, hA₃AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with K_is of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research.

Research Area：Cancer

Targets：Carbonic Anhydrase|Adenosine Receptor

Related Small Molecules:Enpp/Carbonic anhydrase-IN-1;hCAIX-IN-8;MRS 1523;APNEA;Phenylsulfamide;MIPS521;Derenofylline;FSCPX;Benzolamide;Theobromine-d3;(E)-Dehydrodiconiferyl alcohol;Inosine-13C;Norisoboldine;hCAIX/XII-IN-1;N-0861 racemate;CAXII-IN-1;hCAIX/XII-IN-2;hCAIX-IN-12;Girentuximab;Xanthine amine congener dihydrochloride;LUF6096;A1/A3 AR antagonist 1;ATL-801;Istradefylline;Doxofylline-d6

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