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GW779439X
CAS No. : 551919-98-3
Biological Activity：GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus
Research Area：Cancer|Infection
Targets：Bacterial|Aurora Kinase|Apoptosis
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