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GSK481

CAS No. : 1622849-58-4

Biological Activity：GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC₅₀ of 1.3 nM, which inhibits Ser¹⁶⁶ phosphorylation in wild-type human RIP1 (IC₅₀=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC₅₀ of 10 nM.

Research Area：Inflammation/Immunology

Targets：RIP kinase

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Chemical Probe Library;Targeted Diversity Library;Protein-protein Interaction Inhibitor Library;

Related Small Molecules:RIPA-56;RIPK3-IN-2;GSK2983559 free acid;AV123;RIPK1-IN-8;RIP2 kinase inhibitor 2;RIP2 Kinase Inhibitor 4;PK68;GSK-872;RIPK-IN-4;TP-030-2;OD36;TP-030-1;RIPK2-IN-2;GSK3145095;Necrostatin 2;RIPK1-IN-4;RIPK1-IN-15;GSK-843;(Rac)-GSK547;RIPK2-IN-1;RIP2 kinase inhibitor 1;Kongensin A;PROTAC RIPK degrader-6;RIPK1-IN-10

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