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GPI-1046
CAS No. : 186452-09-5
Biological Activity：GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. GPI-1046 improves HIV-associated injury of peripheral nerves[3].
Research Area：Infection|Neurological Disease
Targets：FKBP|HIV
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Related Small Molecules:HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;dTAGV-1-NEG;FC131;Peritassine A;Flavopiridol;SAFit2;TAT (48-57);FGI-106 tetrahydrochloride;(Z)-9-Propenyladenine;Apabetalone;Decanoyl-RVKR-CMK TFA;ONX-0914 TFA;FKBP12 PROTAC dTAG-7;Apelin-36(rat, mouse);Ulonivirine
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