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FzM1
CAS No. : 1680196-54-6
Biological Activity：FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade.
Research Area：Cancer
Targets：Wnt|β-catenin
Related Small Molecules:Wnt/β-catenin agonist 1;ARUK3001185;Gallocyanine chloride;Fz7-21;NRX-252114;Foxy-5 TFA;Wnt/β-catenin agonist 4;JW74;IQ 1;Heparan Sulfate;CDK8-IN-11 hydrochloride;ETC-159;(E)-Ferulic acid-d3;Laduviglusib (GMP);NRX-252262;Toxoflavin;KY-05009;HLY78;Wnt-C59;Wogonin;NCB-0846;KY-02327;CCT031374 hydrobromide;β-catenin-IN-4;Echinacoside;JW67;IWP-4;Triptonide;Prodigiosin
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