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F-1

CAS No. : 2244775-31-1

Biological Activity：F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC₅₀s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALK^WT, ROS1^WT, ALK^L1196M and ALK^G1202R, respectively.

Research Area：Cancer

Targets：ROS Kinase|Anaplastic lymphoma kinase (ALK)

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Lung Cancer Compound Library;

Related Small Molecules:ALK-IN-9;KRCA-0008;Alectinib-d8;Taletrectinib;MS4078;TL13-22;NVP-TAE 684;GGTI-2154 hydrochloride;MitoPQ;ALK5-IN-30;TL13-112;ALK-IN-22;Alectinib;ALK-IN-12;Entrectinib;ALK kinase inhibitor-1;WY-135;Anticancer agent 59;TL13-110;ALK inhibitor 1;Envonalkib;Uniconazole;Anticancer agent 76;Salvigenin;GSK1838705A;RIPK2-IN-1;ROS kinases-IN-1;CJ-2360;Anticancer agent 58

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