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DPTIP-prodrug 18
Biological Activity：DPTIP-prodrug 18 (P18) is a orally active and brain-penetrable prodrug of DPTIP (HY-131002). DPTIP-prodrug 18 is a potent nSMase2 inhibitor. DPTIP-prodrug 18 significantly inhibits IL-1β-induced EV (extracellular vesicle) release by inhibition of nSMase2 (neutral sphingomyelinase-2) activity. DPTIP-prodrug 18 can be used for brain injury research.
Research Area：Inflammation/Immunology
Targets：Phospholipase
Related Small Molecules:GK563;DPTIP;Cambinol;Neomycin sulfate;ONO-RS-082;ARN19874;LEI-401;ST271;Melittin TFA;(S)-Bromoenol lactone;GK187;D-Erythro-dihydrosphingosine-d7;FKGK11;PACOCF3;DL-erythro-Dihydrosphingosine;1-Naphthaleneacetic acid potassium salt;C12 NBD Sphingomyelin;ML-298;sPLA2-X Inhibitor 31;Tanshinone I;(R)-Bromoenol lactone;Ecopladib;LY 178002;CAY10502;(2E)-OBAA;ML348
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