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Doxorubicin
CAS No. : 23214-92-8
Biological Activity：Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy[2]. Doxorubicin inhibits human DNA topoisomerase I with an IC50 of 0.8 μM[3].
Research Area：Cancer|Infection
Targets：Topoisomerase|Autophagy|ADC Cytotoxin|HIV|Mitophagy|Bacterial|Antibiotic|HBV|Apoptosis|AMPK
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;AMPK activator 4;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Antibacterial agent 99
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