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DMX-5804

CAS No. : 2306178-56-1

Biological Activity：DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC₅₀ of 3 nM, a pIC₅₀ of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC₅₀, 8.18), and TNIK/MAP4K7 (pIC₅₀, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.

Research Area：Cardiovascular Disease

Targets：MAP4K

Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Anti-Obesity Compound Library;Targeted Diversity Library;

Related Small Molecules:HPK1-IN-30;HPK1-IN-25;HPK1-IN-18;GNE-495;HPK1-IN-3;HPK1-IN-20;KY-05009;HPK1-IN-24;HPK1-IN-10;NCB-0846;HPK1-IN-11;HPK1-IN-9;SS47;HPK1-IN-26;HPK1-IN-7;HPK1-IN-29;HPK1-IN-14;HPK1-IN-28;HPK1-IN-19;TAK1/MAP4K2 inhibitor 1;FLT3/ITD-IN-4;HPK1-IN-17;DB1113;MAP4K4-IN-3;GNE 220;RET-IN-19;HPK1-IN-27;TL4-12;HPK1-IN-12

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