For research use only. We do not sell to patients.

Disufenton sodium

CAS No. : 168021-79-2

Biological Activity：Disufenton sodium (NXY-059) is the disulfonyl derivative of the neuroprotective spin trap phenylbutynitrone(PBN), both NXY-059, its parent PBN and their hydrolysis/oxidation product MNT are very powerful scavengers of free radicals.
IC50 value:
Target: Neuroprotectant
in vitro: Disufenton sodium is more soluble than the spin trapping agent α-phenyl-N-tert-butyl nitrone (PBN) [1]. In an in vitro blood-brain barrier (BBB) model, 250 mM of Disufenton sodium administered at the onset or up to 4 h after oxygen glucose deprivation (OGD) produces a significant reduction in the increased BBB permeability caused by OGD. Furthermore, OGD produces a huge influx of tissue plasminogen activator across the BBB, which is substantially reduced by Disufenton sodium [2].
in vivo: Disufenton sodium reduces infarct volume in rats subjected to 2 hours of middle cerebral artery occlusion in a dose-dependent manner. At equimolar doses (3.0 mg/kg for Disufenton sodium and 1.4 mg/kg for PBN), Disufenton sodium is more efficacious than PBN. Similar results are obtained when a recovery period of 7 days is allowed. The window of therapeutic opportunity for Disufenton sodium is 3 to 6 hours after the start of recirculation [1]. Disufenton sodium, a free radical-trapping agent, has a substantial protective effect, lessening the disability caused by an experimentally induced stroke in a primate species. Disufenton sodium treatment reduces the overall amount of brain damage by >50% of saline-treatment values, with similar levels of protection afforded to both white and gray matter [3].

Research Area：Neurological Disease

Targets：Reactive Oxygen Species

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Antioxidant Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Anti-COVID-19 Compound Library;Pyroptosis Compound Library;Neuroprotective Compound Library;Mitochondria-Targeted Compound Library;Rare Diseases Drug Library;

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose heptahydrochloride;N-Acetyl-D-cysteine;Topoisomerase I/II inhibitor 3;CYPMPO;Antioxidant agent-5;ROS-ERS inducer 1;Glucosamine-13C hydrochloride;L-Ascorbic acid sodium salt;D-Isofloridoside;L-Carnitine-d3 hydrochloride;Licochalcone D;Euparin;RH-EDA;1,3-Dicaffeoylquinic acid;Antitumor agent-68;Echinocystic acid;Glucosamine-13C6,15N hydrochloride;PI3Kα-IN-8;Maresin 1-d5;Ecabet sodium;Ethoxyquin;Eugenol-d3;Rifamycin S;AKBA;L-Theanine;Chol-CTPP

About Us:

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
Structurally and synthetically diverse biologically active compounds；
roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.

Top Publications Citing Use of MCE Products