Daphnetin

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Daphnetin

CAS No. : 486-35-1

Biological Activity：Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[2][3][4].

Research Area：Inflammation/Immunology|Cancer

Targets：EGFR|Parasite|Akt|PARP|Autophagy|mTOR|Reactive Oxygen Species|PKC|PKA|Bcl-2 Family|Caspase|Apoptosis|AMPK

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