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CSF1R-IN-3

CAS No. : 2760584-90-3

Biological Activity：CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC₅₀=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.

Research Area：Cancer

Targets：c-Fms

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Anti-Colorectal Cancer Compound Library ;

Related Small Molecules:IHMT-TRK-284;Chiauranib;Pexidartinib;GW2580-d6;CSF1R-IN-1;BPR1R024;PF 477736;GENZ-882706(Raceme);c-Fms-IN-7;c-Fms-IN-13;Anti-Mouse GM-CSF Antibody;c-Fms-IN-6;Linifanib;c-Fms-IN-8;c-Fms-IN-9;c-Fms-IN-10;RET-IN-19;GW2580;CSF1R-IN-10;PLX647 dihydrochloride;Cabiralizumab;PLX5622 hemifumarate;OSI-930;CSF1R-IN-8;Dovitinib-d8;Vimseltinib;Ki20227

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