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CCG273441

CAS No. : 2750414-35-6

Biological Activity：CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC₅₀ value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC₅₀=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle.

Research Area：Cancer|Cardiovascular Disease

Targets：G Protein-coupled Receptor Kinase (GRK)

Related Screening Libraries:Bioactive Compound Library Plus; GPCR/G Protein Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Cardiovascular Disease Compound Library;Lipid Metabolism Compound Library ;

Related Small Molecules:GRK6-IN-1;GRK5-IN-2;GRK5-IN-3;GRK-IN-1;KR-39038;CCG-273463;GRK2i;CCG258208;GRK5-IN-4;CCG-271423;GRK6-IN-2;Corazonin

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