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CAY10526
CAS No. : 938069-71-7
Biological Activity：CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1.
Research Area：Cancer
Targets：PGE synthase
Related Small Molecules:Bismuth Subsalicylate;PGS-IN-1;Suprofen;Ethyl Caffeate;HPGDS inhibitor 1;Limaprost-d3;Sinensetin-d3;Vipoglanstat;Isofezolac;HPGDS inhibitor 2;Sinensetin;Cafestol;BRP-201;Zaloglanstat;Clopirac;mPGES-1-IN-1;hPGDS-IN-1;PF-9184;Pranoprofen;mPGES1-IN-3;YS121;Zomepirac sodium salt;Desoxo-narchinol A;AT-56;Dehydroevodiamine
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