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Carbenoxolone-d4

Biological Activity：Carbenoxolone-d4 is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties^[3].
Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the treatment of chronic liver disease^[2].
Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD.
Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop^[4].
Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form.
Carbenoxolone has antiviral activity against DENV infection targeting the virus itself^[6].

Research Area：Infection|Inflammation/Immunology|Neurological Disease

Targets：Amyloid-β|HIV|11β-HSD

Related Small Molecules:β-Amyloid (13-27);BI-135585;Saikosaponin C;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;β-Amyloid (1-42), (rat/mouse) (TFA);Triptonine B;β-Amyloid (12-28) (TFA);FC131;Peritassine A;BuChE-IN-5;Ginsenoside Rg1;MDR-1339;Flavopiridol;TAT (48-57);FGI-106 tetrahydrochloride;AZD8329;(Z)-9-Propenyladenine;ABT-384;Apabetalone;Decanoyl-RVKR-CMK TFA;ONX-0914 TFA

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