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BT2
CAS No. : 34576-94-8
Biological Activity：BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM[2].
Research Area：Metabolic Disease
Targets：Bcl-2 Family
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Anti-Blood Cancer Compound Library;
Related Small Molecules:BI-3812;Pyridoclax;PUMA BH3 TFA;Dehydrocorydaline;Bufarenogin;Murizatoclax;Obatoclax;CYD-2-11;BM 957;(S)-Gossypol (acetic acid);A-385358;Mcl-1 inhibitor 6;S55746;Anticancer agent 63;MCL-1/BCL-2-IN-2;Anticancer agent 65;(E)-Ferulic acid-d3;Bcl-2-IN-8;S65487 hydrochloride;PI-1840;MIK665;WEHI-539;Bax activator-1;UBX1325;Mcl-1 inhibitor 3;Maritoclax;ABT 737-d8
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