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Bromosporine
CAS No. : 1619994-69-2
Biological Activity：Bromosporine is a potent BET inhibitor with an IC50 value of 2.1 μM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-FU (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS[2][3][4].
Research Area：Cancer
Targets：Epigenetic Reader Domain|CDK|HIV|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Kinase Inhibitor Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Antiviral Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Chemical Probe Library;Anti-Breast Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Colorectal Cancer Compound Library ;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;RVX-297;Lobetyolin;BRD4 Inhibitor-19;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Ecteinascidin 770;MDM2-p53-IN-15;Seletracetam lithium;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;HIV-IN-2;CC-671;UNC6349 (Ket2);Xevinapant
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