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Brevetoxin-3
CAS No. : 85079-48-7
Biological Activity：Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].
Research Area：Inflammation/Immunology
Targets：Sodium Channel
Related Small Molecules:Lu AE98134;Zandatrigine;Veratridine;Brompheniramine-d6 maleate;GX-674;Dibucaine;Sodium Channel inhibitor 2;3-Deoxyaconitine;20(S)-Ginsenoside Rg3;Tocainide hydrochloride;Licarbazepine-d4-1;Metaflumizone-d4;β-Pompilidotoxin;Nav1.1 activator 1;ICA-121431;Brompheniramine maleate;ABBV-318;PF 05089771;DPI 201-106;TC-N 1752
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