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Angiotensin (1-7) (acetate)
Biological Activity：Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium[2][3].
Research Area：Endocrinology|Inflammation/Immunology|Cardiovascular Disease
Targets：Angiotensin-converting Enzyme (ACE)|Angiotensin Receptor|Endogenous Metabolite
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