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AMG-548 hydrochloride

Biological Activity：AMG-548 hydrochloride, an orally active and selective p38α inhibitor (K_i=0.5 nM), shows slightly selective over p38β (K_i=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 hydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC₅₀=3 nM). AMG-548 hydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε^[2].

Research Area：Inflammation/Immunology

Targets：p38 MAPK|Casein Kinase

Related Small Molecules:Umbralisib hydrochloride;SB-747651A dihydrochloride;Dehydrocorydaline;SKF-86002 dihydrochloride;4,5,6,7-Tetrabromo-1H-benzimidazole;Pexmetinib;SB 242235;TA-01;Ellagic acid;Anti-inflammatory agent 7;CK2 inhibitor 3;MW-150;VX-702;TMCB;R1487 Hydrochloride;MBP MAPK Substrate;Isoliquiritin apioside;Sesamolin;CK2 inhibitor 2;MAPK13-IN-1;PF-05381941;Longdaysin;Semapimod tetrahydrochloride;D4476;SD-169;Skatole;BMS-582949 hydrochloride;Gypenoside L

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