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AMG-1694
CAS No. : 1361217-07-3
Biological Activity：AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation. AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.
Research Area：Metabolic Disease
Targets：Glucokinase
Related Small Molecules:PF-04937319;Globalagliatin;Palmitelaidic Acid;Glucokinase activator 1;AZD1656;AMG-3969;RO-28-1675;IHVR-11029;Cadisegliatin;PSN-GK1;Glucokinase activator 3;PF-04991532;Dorzagliatin;AR453588 hydrochloride;GKA50 quarterhydrate;Palmitelaidic acid-d13;BMS-820132;MK-0941 free base;AM-2394
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