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AGI-6780

CAS No. : 1432660-47-3

Biological Activity：AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2^R140Q with IC₅₀ of 23±1.7 nM. AGI-6780 is less potent against IDH2^WT with IC₅₀ of 190±8.1 nM.

Research Area：Cancer

Targets：Isocitrate Dehydrogenase (IDH)

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Covalent Screening Library;Glutamine Metabolism Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;

Related Small Molecules:mIDH1-IN-1;Enasidenib mesylate;AGI-12026;IDH1 Inhibitor 2;DS-1001b;BAY-1436032;Mutant IDH1-IN-1;(R,S)-Ivosidenib;AGI-5198;IDH-C227;IDH1 Inhibitor 1;Mutant IDH1-IN-6;Olutasidenib;IDH-305;IDH1 Inhibitor 3;IDH2R140Q-IN-1;Vorasidenib;(S,R)-GSK321;IDH889;IDH1 Inhibitor 5;Mutant IDH1 inhibitor;Mutant IDH1-IN-2;Mutant IDH1-IN-4;GSK864

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