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AA147
CAS No. : 393121-74-9
Biological Activity：AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection[2][3][4].
Research Area：Metabolic Disease|Neurological Disease
Targets：Reactive Oxygen Species|ATF6
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