5-O-Demethylnobiletin

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5-O-Demethylnobiletin

CAS No. : 2174-59-6

Biological Activity:5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM.

Research Area:Inflammation/Immunology|Neurological Disease|Cancer

Targets:Leukotriene Receptor|Lipoxygenase

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Related Small Molecules:COX-2/5-LOX-IN-3;Pranlukast-d4;Verlukast-d6;A-69412;5-LOX-IN-1;Atreleuton;S-(+)-Marmesin;Ablukast;CP-96486;MK-886;Malotilate;Phenidone;2-TEDC;BW B70C;ALOX15-IN-2;PGS-IN-1;BIIL-260 hydrochloride;Pranlukast;ALOX15-IN-1;Ro 3-1314;Isothymusin;γ-Linolenic acid ethyl ester;REV 5901;Indirubin-3′-monoxime;U-75302;RS-601;S-2474

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