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YS-370
CAS No. : 2470908-79-1
Biological Activity：YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.
Research Area：Cancer
Targets：P-glycoprotein
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Anti-Cancer Compound Library;Orally Active Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Biricodar;P-gp inhibitor 4;Sinapine thiocyanate;Dofequidar fumarate;Elacridar;Coniferyl ferulate;Anticancer agent 50;Valspodar;P-gp inhibitor 1;Boeravinone B;Solamargine;Polyoxyethylene stearate;TTT-28;CP-100356 hydrochloride;Epoxylathyrol;Chrysosplenetin;Zamicastat;Tariquidar;P-gp modulator 3;Roemerine;Coleon-U-quinone;Zosuquidar trihydrochloride;Encequidar;P-gp modulator 1
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