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Vinpocetine

CAS No. : 42971-09-5

Biological Activity：Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders^[2]^[3].

Research Area：Inflammation/Immunology|Neurological Disease|Cardiovascular Disease|Cancer

Targets：Phosphodiesterase (PDE)|Sodium Channel|IKK

Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Natural Product Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Anti-Cardiovascular Disease Compound Library;NMPA-Approved Drug Library;Medicine Food Homology Compound Library;Pyroptosis Compound Library;Traditional Chinese Medicine Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Alzheimer’s Disease Compound Library;Neuroprotective Compound Library;Alkaloids Library;Neurodegenerative Disease-related Compound Library;Mechanoreceptors Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Cancer Natural Product Library; Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Sodium Channel Blocker Library;FDA-Approved Anticancer Drug Library;Anti-Prostate Cancer Compound Library;Non-steroidal Anti-Inflammatory Compound Library;Anti-Aging Natural Product Library;

Related Small Molecules:Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;Lu AE98134;ATX inhibitor 22;Carbazeran citrate;Zandatrigine;Bay 60-7550;BC11-38;Deltarasin hydrochloride;Glaucine;Veratridine;Brompheniramine-d6 maleate;GX-674;Ziritaxestat;Dibucaine;PS-1145;Udenafil-d7;D159687;ITI-214;NF-κB-IN-1;Sodium Channel inhibitor 2;PDE10-IN-5;3-Deoxyaconitine;20(S)-Ginsenoside Rg3;Resveratrol

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