For research use only. We do not sell to patients.
SZM679
Biological Activity：SZM679 is a potent, orally active and selective RIPK1 inhibitor with Kd values of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. SZM679 reverses the tumor necrosis factor-induced systemic inflammatory response. SZM679 decreases the Tau hyperphosphorylation, neuroinflammation, and the RIPK1 phosphorylation level in the hippocampus and cortex. SZM679 can be used in research of Alzheimer’s disease (AD).
Research Area：Inflammation/Immunology
Targets：RIP kinase
Related Small Molecules:RIPA-56;RIPK3-IN-2;GSK2983559 free acid;AV123;RIPK1-IN-8;RIP2 kinase inhibitor 2;RIP2 Kinase Inhibitor 4;PK68;GSK-872;RIPK-IN-4;TP-030-2;OD36;TP-030-1;RIPK2-IN-2;GSK3145095;Necrostatin 2;RIPK1-IN-4;RIPK1-IN-15;GSK-843;(Rac)-GSK547;RIPK2-IN-1;RIP2 kinase inhibitor 1;Kongensin A;PROTAC RIPK degrader-6;RIPK1-IN-10
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Structurally and synthetically diverse biologically active compounds；
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