For research use only. We do not sell to patients.

RdRP-IN-4

Biological Activity：RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice.

Research Area：Infection

Targets：Influenza Virus

Related Small Molecules:Curcumin;(R)-Camptothecin-d5;Glaucine;Hypericin;Neuraminidase-IN-3;FGI-106 tetrahydrochloride;Molnupiravir;Onradivir;SP187;Nuezhenidic acid;Ketotifen fumarate;Baloxavir-d5;Coptisine chloride;Ginsenoside Rb2;T-1105;Tetrahydroepiberberine;JNJ4796;Loratadine-d5;Camptothecin;Eriodictyol;Catechin-13C3;Dendrobine;N-Glycolylneuraminic acid;Clovamide;Influenza A NP(366-374) Strain A/PR/8/35;Rose Bengal sodium;Psoralen

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

About Us:

• MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
• Structurally and synthetically diverse biologically active compounds；
•  roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
• We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
• Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

• Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.