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PD98059

CAS No. : 167869-21-8

Biological Activity：PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀ of 1 μM). PD98059 also inhibits autophagy^[2]^[3].

Research Area：Cancer

Targets：MEK|Autophagy|Aryl Hydrocarbon Receptor|ERK

Related Screening Libraries:Natural Product-like Compound Library;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Glutamine Metabolism Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:Avutometinib;Cobimetinib racemate;Corynoxeine;EBI-1051;Temuterkib;CHMFL-EGFR-202;FICZ;MeBIO;AhR agonist 2;Indole-3-pyruvic acid;CKLF1-C27;LM22B-10;ERK5-IN-4;BI-847325;Pachymic acid;MAP855;Benzyl butyl phthalate;L-Kynurenine-d4-1;Pifithrin-α hydrobromide;6-OAU;VX-11e;Pluripotin;2,5-Dihydroxyacetophenone

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