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NPS-2143 hydrochloride

CAS No. : 324523-20-8

Biological Activity：NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca²⁺ concentrations (IC₅₀=43 nM) elicited by activating the Ca²⁺ receptor in HEK 293 cells expressing the human Ca²⁺ receptor^[2].

Research Area：Metabolic Disease

Targets：CaSR

Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Orally Active Compound Library;

Related Small Molecules:Calcium-Sensing Receptor Antagonists I;Calhex 231 hydrochloride;SB-423562;Ligustroflavone;NPS 2390;AC-265347;GSK3004774;Etelcalcetide hydrochloride;Gadolinium chloride;Upacicalcet;Strontium Ranelate;NPS-2143;γ-L-Glutamyl-L-alanine;SB-423557;Tecalcet Hydrochloride;Evocalcet

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