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NPS-2143
CAS No. : 284035-33-2
Biological Activity：NPS-2143 (SB-262470A), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 (SB-262470A) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor[2].
Research Area：Metabolic Disease
Targets：CaSR
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Orally Active Compound Library;Targeted Diversity Library;
Related Small Molecules:Calcium-Sensing Receptor Antagonists I;Calhex 231 hydrochloride;SB-423562;Ligustroflavone;NPS 2390;AC-265347;GSK3004774;Etelcalcetide hydrochloride;Gadolinium chloride;Upacicalcet;Strontium Ranelate;γ-L-Glutamyl-L-alanine;SB-423557;Tecalcet Hydrochloride;Evocalcet
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