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Nonapeptide-1 acetate salt
Biological Activity：Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC50: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer[2][3].
Research Area：Cancer|Endocrinology|Metabolic Disease
Targets：Melanocortin Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Anti-Cancer Compound Library;Macrocyclic Compound Library;Endocrinology Compound Library;Peptide Library;Cyclic Peptide Library;
Related Small Molecules:Bremelanotide;MSG606 TFA;Resomelagon;Dersimelagon;Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA;Terrein;γ1-MSH TFA;SNT-207707;PF-07258669;THIQ;ACTH (11-24) (acetate);JKC363 TFA;PG-931 TFA;[D-Trp8]-γ-MSH;MC-4R Agonist 1;ACTH (1-17);SNT-207858 free base;Lys-γ3-MSH(human);Nonapeptide-1;HS024 TFA;Adrenocorticotropic Hormone (ACTH) (4-10), human;SHU 9119;Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA);(p-Iodo-Phe7)-ACTH (4-10)
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