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N1,N11-Diethylnorspermine
CAS No. : 121749-39-1
Biological Activity：N1,N11-Diethylnorspermine (DENSPM) is a potent anticancer agent. N1,N11-Diethylnorspermine is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production[2][3].
Research Area：Cancer
Targets：Caspase
Related Small Molecules:Dehydrocorydaline;Z-DEVD-AMC;p-nitro-Pifithrin-α;ML132;L67;AKN-028 acetate;Ossirene;δ-Secretase inhibitor 11;Anticancer agent 63;Fenbufen-d9;Penicillic acid;Sesamolin;PI-1840;5,7-Dihydroxychromone;HDAC1-IN-5;Ac-DEVD-pNA;Crustecdysone;Caspase-3-IN-1;PARP-1-IN-2;Z-WEHD-FMK;Mca-YVADAP-Lys(Dnp)-OH;Aspirin;BOC-D-FMK;Ac-LEHD-AFC;Asperosaponin VI;Thevetiaflavone
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