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ML351
CAS No. : 847163-28-4
Biological Activity：ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D[2].
Research Area：Metabolic Disease|Neurological Disease
Targets：Lipoxygenase
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Related Small Molecules:COX-2/5-LOX-IN-3;A-69412;5-LOX-IN-1;Atreleuton;S-(+)-Marmesin;Malotilate;Phenidone;2-TEDC;BW B70C;ALOX15-IN-2;PGS-IN-1;ALOX15-IN-1;Ro 3-1314;Isothymusin;REV 5901;Indirubin-3′-monoxime;S-2474;Enazadrem;RWJ 63556;LY 178002;Xanthatin;CAY10698;Psoralidin;FPL 62064;11-Keto-beta-boswellic acid;Tepoxalin;β-Boswellic acid;Masoprocol;CJ-13,610
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