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MAC glucuronide α-hydroxy lactone-linked SN-38

CAS No. : 2246380-70-9

Biological Activity：MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker. MAC glucuronide α-hydroxy lactone-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC₅₀ values of 99 and 105 ng/mL, respectively.

Research Area：Cancer

Targets：Drug-Linker Conjugates for ADC

Related Small Molecules:L-Asparagine-N-Fmoc,N-beta-trityl-15N2;Val-Cit-PAB-MMAF sodium;MC-VC-PABC-SP 141;Deruxtecan analog 2;PSMA-ALB-56;Gly3-VC-PAB-MMAE;MP-PEG8-Val-Lys-Gly-7-MAD-MDCPT;Tesirine;SPB;(Rac)-Lys-SMCC-DM1;VcMMAE;MC-Alkyl-Hydrazine Modified MMAF;Mc-MMAE;DGN549-L;MC-VA-PAB-Exatecan;MC-SN38;DBCO-(PEG2-VC-PAB-MMAE)2;DBCO-PEG4-MMAF;NAMPT inhibitor-linker 2;DM4-SPDP;SuO-Glu-Val-Cit-PAB-MMAE;MC-DOXHZN;Mal-PEG4-VC-PAB-DMEA-Seco-Duocarmycin SA;SPP-DM1;DBCO-PEG4-VC-PAB-DMEA-PNU-159682;Fmoc-Val-Cit-PAB-MMAE;DBCO-(PEG)3-VC-PAB-MMAE

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