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LPM4870108

Biological Activity：LPM4870108 is a potent and orally active pan-Trk (WT and MT) inhibitor, with IC₅₀s of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkA^G595R and TrkA^G667C, respectively. LPM4870108 shows selectivity for Trk over ALK (IC₅₀=182 nM). LPM4870108 exhibits anti-tumor activity^[2].

Research Area：Cancer

Targets：Trk Receptor

Related Small Molecules:hTrkA-IN-1;IHMT-TRK-284;ANA-12;Larotrectinib sulfate;N-Acetyl-5-hydroxytryptamine;LM22B-10;D5261;N-Acetyl-5-hydroxytryptamine-d3;7,8-Dihydroxyflavone;TRK-IN-18;TRK-IN-12;CH7057288;Entrectinib;Pan-Trk-IN-3;ONO-7475;AZ-23;Trk-IN-6;GNF-5837;Cyclotraxin B;TrkA-IN-1;PF-06737007;TRK II-IN-1;Trk-IN-10;Trk-IN-9;Trk-IN-1;Sacibertinib;Pan-Trk-IN-2;TRK-IN-13

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