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HDAC6-IN-5

CAS No. : 2413603-15-1

Biological Activity：HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC₅₀ of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ_1-42 self-aggregation and AChE, with IC₅₀ values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.

Research Area：Neurological Disease

Targets：HDAC|Amyloid-β|Cholinesterase (ChE)

Related Small Molecules:β-Amyloid (13-27);Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);Piperilate;β-Amyloid (12-28) (TFA);Pivanex;BuChE-IN-5;Crotonoside;MPT0B390;Ginsenoside Rg1;MDR-1339;AChE/BChE-IN-10;RSC133;Timosaponin AIII;HDAC1/6-IN-1;HDAC/HSP90-IN-4;Trimyristin;AChE-IN-10;JPS014;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;β-Amyloid (11-22);HDAC-IN-4;Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11

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