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Fenobam
CAS No. : 57653-26-6
Biological Activity：Fenobam is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity[2].
Research Area：Neurological Disease
Targets：mGluR
Related Screening Libraries:Covalent Screening Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Clinical Compound Library;CNS-Penetrant Compound Library;Covalent Screening Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library;Neuroprotective Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Antidepressant Compound Library;Protein-protein Interaction Inhibitor Library;Human Metabolite Library;
Related Small Molecules:LY3020371 hydrochloride;ZJ43;FPTQ;(S)-MCPG;mGluR2 modulator 1;VU6010572;Mavoglurant racemate;DFMTI;JNJ16259685;Auglurant;FITM;(-)-Camphoric acid;LY367385 hydrochloride;Cinnabarinic acid;LY379268;AZD 9272;mGluR2 antagonist 1;ABP688;FTIDC;MPPG;L-AP3;VU6001966;VU0155041 sodium;VU 0364439;trans-ACPD;AZD-8529 mesylate;VU 0357121;PHCCC;HexylHIBO;VU0650786
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