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Dyclonine hydrochloride
CAS No. : 536-43-6
Biological Activity：Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 µM for ALDH2 and 76 µM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[2][3].
Research Area：Cancer|Infection
Targets：Fungal|Bacterial|Aldehyde Dehydrogenase (ALDH)
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Peptidomimetic Library;Drug Repurposing Compound Library;Antifungal Compound Library;Antibacterial Compound Library;NMPA-Approved Drug Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Cancer Metabolism Compound Library;FDA-Approved Anticancer Drug Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Antifungal agent 20;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Debneyol;Leucomycin;Isouvaretin;Haloprogin;Antibacterial agent 99;Nafcillin;Antitubercular agent-28;Ochromycinone;Staurosporine;Nucleocidin;(±)-Leucine-13C-1;Ciclopirox-d11;Ciclopirox olamine;Clotrimazole-d5;SQ109
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