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Doramapimod
CAS No. : 285983-48-4
Biological Activity：Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod has picomolar affinity for p38 kinase (Kd=0.1 nM). Doramapimod also inhibits B-Raf with an IC50 of 83 nM[2].
Research Area：Inflammation/Immunology|Cancer
Targets：Autophagy|Raf|p38 MAPK
Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Autophagy Compound Library;Drug Repurposing Compound Library;Covalent Screening Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Anti-COVID-19 Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Avutometinib;AZ 628;SB-747651A dihydrochloride;Dehydrocorydaline;SKF-86002 dihydrochloride;Pexmetinib;SB 242235;Everafenib;TA-01;Anti-inflammatory agent 7;L-779450;MW-150;VX-702;R1487 Hydrochloride;Raf inhibitor 1;MBP MAPK Substrate;Isoliquiritin apioside;Sesamolin;PLX-4720;RRD-251;B-Raf IN 8;MAPK13-IN-1;PF-05381941;TAK-632;Encorafenib;Semapimod tetrahydrochloride
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