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DC0-NH2
CAS No. : 615538-51-7
Biological Activity：DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer drugs (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component.
Research Area：Cancer
Targets：ADC Cytotoxin
Related Screening Libraries:Bioactive Compound Library Plus;Toxins for Antibody-Drug Conjugate Research Library;
Related Small Molecules:Sandramycin;(R)-Camptothecin-d5;Dolastatin 10;INX-SM-56;DC10SMe;Rebeccamycin;Duocarmycin TM;Fmoc-MMAE;Taltobulin;N-Me-L-Ala-maytansinol;CC-885-CH2-PEG1-NH-CH3;Camptothecin;Maytansinol;Tomaymycin DM;Hemiasterlin derivative-1;SGD-1882;Corixetan;Duostatin 5;PROTAC BRD4 Degrader-13;Dxd-d5;Tubulysin IM-1;Duocarmycin SA;Ansamitocin P 3′;PNU-159682 carboxylic acid;Duocarmycin DM free base
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