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CZC-54252 hydrochloride

CAS No. : 1784253-05-9

Biological Activity：CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC₅₀s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC₅₀ of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.

Research Area：Neurological Disease

Targets：LRRK2

Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Autophagy Compound Library;Neuroprotective Compound Library;Anti-Parkinson’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;

Related Small Molecules:LRRK2 inhibitor 1;CZC-25146;LRRK2-IN-2;GNE0877;IKK 16;LRRK2-IN-1;EB-42486;XL01126;PFE-360;GSK2646264;PF-06454589;LRRK2-IN-5;PF-06456384 trihydrochloride;PF-06455943;LRRK2-IN-4;JH-II-127;GSK2578215A;LRRK2-IN-6;GNE-9605;GNE-7915;CZC-54252;MLi-2;Indazole;HG-10-102-01;PF-06447475

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