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CAY10789

CAS No. : 123226-28-8

Biological Activity：CAY10789 (compound 6) is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist (IC₅₀=2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist (EC₅₀=3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.

Research Area：Metabolic Disease|Inflammation/Immunology

Targets：TNF Receptor|Leukotriene Receptor|G protein-coupled Bile Acid Receptor 1

Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;Pranlukast-d4;QNZ;Sinulatumolin E;Verlukast-d6;Hyodeoxycholic acid-d5;Epobis;Cholic acid 7-sulfate;Mulberroside A;Sinulatumolin D;PDE4-IN-10;Ginsenoside Rc;Deoxycholic acid-13C;Ablukast;CP-96486;TIC10;MK-886;Teneliximab;Loganic acid 6′-O-β-D-glucoside;VGX-1027;D-Trimannuronic acid;DCVC;BIIL-260 hydrochloride;Gamma-glutamylcysteine TFA;Deoxycholic acid sodium hydrate;Pranlukast;Varlilumab

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