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Belnacasan
CAS No. : 273404-37-8
Biological Activity：Belnacasan (VX-765) is an orally bioactive prodrug of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM[2].
Research Area：Inflammation/Immunology
Targets：Caspase
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Clinical Compound Library;Peptidomimetic Library;Drug Repurposing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Targeted Diversity Library;Antidepressant Compound Library;
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