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APD668
CAS No. : 832714-46-2
Biological Activity：APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki=0.1 μM). APD668 can be used for the research of steatohepatitis and diabetes[2].
Research Area：Metabolic Disease
Targets：GPR119|Potassium Channel|Cytochrome P450
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Membrane Transporter/Ion Channel Compound Library;Metabolism/Protease Compound Library;Neuronal Signaling Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Anti-diabetic Compound Library;Oxygen Sensing Compound Library;Orally Active Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Potassium Channel Compound Library;Human Metabolite Library;
Related Small Molecules:SR9186;AMG-208;Kv3 modulator 2;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;Brompheniramine-d6 maleate;Hypericin;Pinacidil;AMP-PNP tetralithium;IK1 inhibitor PA-6;VU590;Galeterone;Ranitidine;Domiphen bromide;Mesoridazine benzenesulfonate;Bergapten;Tetrandrine;20(S)-Ginsenoside Rg3;Ginsenoside Rd;(S)-(+)-Modafinic acid-d5;AS1810722;Isoglycycoumarin
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