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Anatabine dicitrate
Biological Activity：Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine dicitrate has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment[2][3].
Research Area：Inflammation/Immunology|Neurological Disease
Targets：nAChR|NF-κB|Amyloid-β
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Differentiation Inducing Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Neurotransmitter Receptor Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:β-Amyloid (13-27);Akt/NF-κB/JNK-IN-1;Icariside F2;Saikosaponin C;IKKγ NBD Inhibitory Peptide TFA;Mangiferin;Antioxidant agent-5;β-Amyloid (1-42), (rat/mouse) (TFA);Spinosad;ALPK1-IN-1;Regaloside A;β-Amyloid (12-28) (TFA);Pyrantel;IMD-ferulic;SN52;BuChE-IN-5;5-Aminosalicylic Acid-D3 hydrochloride;Ginsenoside Rg1;Echinulin;MDR-1339;Licochalcone D;QNZ;BIZ 114;NF-κΒ activator 1;Berbamine
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