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3-Hydroxy Midostaurin
CAS No. : 179237-49-1
Biological Activity：3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412.
Research Area：Cancer
Targets：FLT3
Related Small Molecules:AT9283;(E/Z)-Zotiraciclib;Crotonoside;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;HP1142;ENMD-2076 Tartrate;ATH686;AZD2932;AKN-028 acetate;FLT3-IN-3;UNC2025 hydrochloride;Tandutinib;Gilteritinib-d8;PF 477736;(R)-3-Hydroxy Midostaurin;BSc5371;OTS447;PDGFRα/FLT3-ITD-IN-1;TAK-659 hydrochloride;FLT3-IN-4;JNJ-47117096 hydrochloride;FLT3-IN-14;MAX-40279 hemiadipate
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