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TPX-0131

CAS No. : 2648641-36-3

Biological Activity：TPX-0131 is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC₅₀ of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC₅₀ of 0.3 nM), L1196M (IC₅₀ of 0.3 nM). TPX-0131 has strong antitumor activities.

Research Area：Cancer

Targets：Anaplastic lymphoma kinase (ALK)

Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Orally Active Compound Library;

Related Small Molecules:ALK-IN-9;KRCA-0008;Alectinib-d8;MS4078;TL13-22;NVP-TAE 684;ALK5-IN-30;TL13-112;ALK-IN-22;Alectinib;ALK-IN-12;Entrectinib;ALK kinase inhibitor-1;WY-135;TL13-110;ALK inhibitor 1;Envonalkib;GSK1838705A;RIPK2-IN-1;CJ-2360;ALK-IN-1;ALK5-IN-29;X-376;ALK-IN-21;Repotrectinib;Lorlatinib;M4K2234;MS4077

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