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Rosuvastatin Calcium
CAS No. : 147098-20-2
Biological Activity：Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM[2]. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels[2][3].
Research Area：Metabolic Disease|Cardiovascular Disease|Cancer
Targets：Autophagy|Potassium Channel|Bacterial|HMG-CoA Reductase (HMGCR)
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